|Dr. Shane L. Phillips
|Assistant Professor of
||California State University, Stanislaus
|Ph.D. Inorganic Chemistry
||University of California, Davis
My research interests are in the areas of inorganic and
bioinorganic chemistry. In general, I seek to synthesize new compounds with
interesting physical and chemical properties. Some specific examples are detailed
Some of my published work involves the synthesis of
organometallic porphyrin models of heme enzyme active sites to examine the chemical
reactivity, coordination chemistry and structural features of these complexes and their
relationship to natural, biological systems. Iron porphyrin compounds such as heme
(see structure below) are particularly amenable for study by nuclear magnetic resonance
spectroscopy which can discriminate between metal oxidation states, spin states, and
A second research project involves the coordination
chemistry of some classical cobalt (III) compounds. A series of tetramines have been
found to bind to cobalt in a variety of modes including structural and stereoisomers.
I am interested in understanding the properties that lead to the various stable
isomers of these complexes. Parallel studies using computer modeling are being used
to study these compounds.
I am also interested in the coordination chemistry and catalytic
properties of complexes containing metal-metal bonds. I first became enamored with
these compounds because of the anticancer activity exhibited by dirhodium tetracetate (see
structure below). During my postdoctoral investigation into the mechanism of nucleobase
binding and general reactivity of this compound, I discovered the formation of an
unprecedented, linear tetrarhodium cluster containing three Rh-Rh bonds. The
synthesis of supramolecular linear metallic chains, e.g. "molecular wires", is
an exciting prospect with the ultimate goal of developing materials with technologically
useful physical and chemical properties.
- Phillips, S.L.; Huffman, J.C.; Christou, G. The
First Example of N7,O6-Guanine Chelation as Exhibited by a Dinuclear Rhodium(II)
Carboxylate Complex. Manuscript in preparation.
- Phillips, S.L.; Huffman, J.C.; Christou, G. Remarkable
Formation of an Unprecedented Linear Tetrarhodium(II) Complex Containing Three Metal-Metal
Bonds. Manuscript in preparation.
- Phillips, S.L.; Huffman, J.C.; Christou, G. A
Dinuclear Rhodium(II) Carboxylate Complex Containing a Novel Adenine Binding Mode.
Manuscript in preparation.
- Koerner, R.; Olmstead, M.M.; Ozarowski, A.;
Phillips, S.L.; Van Calcar, P.M.; Winkler, K.; Balch, A.L.; Possible Intermediates in
Biological Metalloporphyrin Oxidative Degradation. Nickel, Copper and Cobalt Complexes of
Octaethylformylbiliverdin and Their Conversion to a Verdoheme. J. Am. Chem. Soc.
1998, 120, 1274.
- Phillips, S.L.; Arasassingham, R.D.; Balch,
A.L.; Olmstead, M.M. Paramagnetic Iron(III) and Diamagnetic Gallium(III) Porphyrins
Complexes with Axial Allyl and Vinyl Ligands. Inorg. Chim. Acta. 1997,
- Phillips, S.L; Balch, A.L.; Noll, B.C.; M.M.
Olmstead. Structural and Spectroscopic Characterization of Iron(III)
Dioxoporphodimethene Complexes and Their Autoreduction to an Iron(II) Complex in Pyridine,
Inorg. Chem. 1996, 35, 6495.
- Phillips, S.L.; Balch, A.L.; Latos-Grazynski,
L.; Noll, B.C. Acetylide Complexes of Diamagnetic Gallium(III) and Paramagnetic
Iron(III) Porphyrins. Inorg. Chem. 1993, 32, 1124.
- Phillips, S.L; Balch, A.L.; M.M. Olmstead. Identification
of Isomeric meso-Dioxo Derivatives of Octaethylporphyrin and Separation and Structural
Characterization of the Nickel(II) Complexes. Inorg. Chem. 1993, 32,
- Balch, A.L.; Noll, B.C.; Phillips, S.L.;
Reid, S.M.; Zovinka, E.P. Nickel(II) Complexes of the Octaethyloxophlorin Radical
Dianion. Inorg. Chem. 1993, 32, 4730.